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DS-01 with the acrylamideprolinol motif enabled the degradation of pan-KRAS To investigate whether this chemical strategy could be extended to develop degraders against a broad-spectrum of KRAS mutations, we incorporated the acrylamideprolinol motif into a pan-KRAS inhibitor structurally similar to MRTX849 (both developed by Mirati Therapeutics) 66 , successfully designing and synthesizing DS-01 (Fig

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